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Pimpodkar, Nayana V.
- Bioanalytical Method Validation
Authors
1 College of Pharmacy (D.Pharm) Degaon, Satara, (MH) - 415 004, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 4 (2015), Pagination: 219-225Abstract
The Bioanalytical method validation includes all of the procedures that demonstrate a particular method used for a quantitative measurement of analytes in a given biological matrix is selective, sensitive, reliable and reproducible for the deliberate use. Measurement of drug concentrations in biological matrices is an important aspect of medicinal product development for those products containing new active substances and generic products. Such data may be required to support new applications as well as variations to licensed drug products. The results of toxic kinetic, pharmacokinetic and bioequivalence studies are used to make critical decisions supporting the safety and efficacy of a medicinal drug substance or product. It is therefore paramount that the applied Bioanalytical methods used are well characterized, fully validated and documented to a satisfactory standard in order to yield reliable results.Keywords
BMV-Bioanalytical Method Validation.- A Compressive Review on the Study of Nanotechnology for Herbal Drugs
Authors
1 College of Pharmacy (D.Pharm), Degaon, Satara, (MH) - 415 004, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 4 (2015), Pagination: 203-207Abstract
The traditional medicine system is gaining wider popularity in the present times leading to increase in its commercialization at an international level. Ayurveda can serve as an excellent template for the development of nanomedicine for human theragnostics. Nanoparticals are colloidal systems with particles verying in size from 10 nm to 100 nm. The nano formulations are reportated to have remarkable advantages over respective crude drugs preparations and conventional formulations of plant actives or extracts which includes enhancement of solubility, bioavaibility, protection from toxicity, enhancement of pharmacological activity, reduction in dose enhancement of stability, improved tissue macrophages distribution, sustained delivery and protection from physical and chemical degradation. The present study shows that traditional medicines may hold strong relevance in the emerging era of nanomedicine. Thus nano sized novel drug delivery system of herbal drugs has a potential future for enhancing the activity and overcoming problem associative with herbals.Keywords
Herbal Drugs, Nanomedicine, Novel Drug Delivery System.- An Overview on A Pyrazole:Promising Moiety
Authors
1 College of Pharmacy (D.Pharm) Degaon, Satara, (MH) - 415, IN
2 College of Pharmacy (D.Pharm) Degaon, Satara, (MH) - 415 004, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 4 (2015), Pagination: 201-213Abstract
This review highlighted recent reports of antimicrobial, anticancer, ACE inhibitor, antiviral as well as anti-inflammatory activities of pyrazole. The heterocyclic compound play an important role in organic chemistry and biological chemistry for their rich functionality. It is an important pharmacore and synthesis in the field of organic chemistry and drug designing. It is vast and expanding area of chemistry because of obvious application of compounds derived from heterocyclic rings in pharmacy, medicine, agriculture, plastic, polymer and other fields. Heterocyclic compounds are widely distributed in nature. By virtue of their therapeutic properties; they could be employed in the treatment of infectious diseases. Amongst the various heterocycles, pyrazole classes of compounds play an important role in medicinal chemistry.Keywords
Pyrazole, Photoluminescence Activity, Anti-Inflammatory Activity etc.- Spherical Crystallization:Novel Technique
Authors
1 College of Pharmacy (D.Pharm), Degaon, Satara (MH) - 415004, IN
2 College of Pharmacy (D.Pharm) Degaon, Satara (MH) - 415004, IN
Source
Asian Journal of Pharmacy and Technology, Vol 4, No 3 (2014), Pagination: 151-156Abstract
Spherical crystallization is the novel agglomerated technique that can directly transform the fine crystals produced in the crystallization process into a spherical shape. It is the particle engineering technique by which crystallization and agglomeration can be carried out simultaneously in one step to transform crystals directly into compacted spherical form. This technique of particle design of drugs has emerged as one the areas of active research currently of interest in pharmaceutical manufacturing and came into the forefront of interest or gained interest due to the fact that crystal habit can be modified during crystallization process which would result in better micromeritic properties. Prepared spherical crystals can be compresses directly without performing granulation, drying and so many steps those are required in wet granulation and in dry granulation process of tablet manufacturing.
General methods of spherical crystallization are spherical agglomeration, emulsion solvent diffusion, and ammonia diffusion method. The principle steps involved in the process of spherical crystallization are flocculation zone, zero growth zone, fast growth zone, and constant size zone. Factors controlling the process of agglomeration are solubility profile, mode and intensity of agitation, temperature of the system, and residence time. Spherical crystallization is having wide applications in pharmaceuticals like improvement of flow ability and compressibility of poorly compressible drugs, masking bitter taste of drugs and improving the solubility and dissolution rate of poorly soluble drugs.
Keywords
Spherical Crystallization, Agglomeration Technique, Agglomeration.- A Comprehensive Review on Biodegradable Polymers
Authors
1 College of Pharmacy (D. Pharm), Degaon, Satara (MH) 415 004, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 2 (2016), Pagination: 65-76Abstract
Biodegradable polymers have been widely used in biomedical applications because of their known biocompatibility and biodegradability. Degradable polymeric biomaterials are preferred candidates for developing therapeutic devices such as temporary prostheses, three dimensional porous structures as scaffolds for tissue engineering and as controlled/sustained release drug delivery vehicles. Biodegradable materials are used in packaging, agriculture, medicine and other areas. In the biomedical area, polymers are generally used as implants and are expected to perform long term service. These improvements contribute to make medical treatment more efficient and to minimize side effects and other types of inconveniences for patients. The following review presents an overview of the different biodegradable polymers and their applications.Keywords
Biodegradable, Biocompatibility, Polymers.- Quality by Design
Authors
1 College of Pharmacy (D. Pharm), Degaon, Satara (MH)-415 004, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 1 (2016), Pagination: 45-50Abstract
Quality by design (QbD) is an essential part of the modern advance to pharmaceutical quality. QbD is best key to build a quality in all pharmaceutical products. Under this concepts of Be throughout design and growth of product, it is important to identify desire product performance report [Target product profile (TPP), Quality Target product profile (QTPP)] and identify critical quality attributes (CQA). To recognize the impact of raw material [critical material attributes (CAM)], critical process parameters (CPP) on the CQAs and identification and control sources of changeability. The plan of pharmaceutical development is to design a quality products and its manufacturing process always deliver the future performance of the product. The base of Quality by design is ICH Guidelines Q8 for Pharmaceutical for development, Q9 quality risk management, Q10 for pharmaceutical quality systems.Keywords
QBD-Quality by Design.- Role of Dental and Healthcare Professionals in Preventing Oral Cancer
Authors
1 College of Pharmacy (D.Pharm), Degaon, Satara (MH) - 415 004, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 4 (2015), Pagination: 239-246Abstract
Oral cavity cancer, or just oral cancer, is cancer that start in the mouth (also called the oral cavity). Oropharyngeal cancer starts in the oropharynx, which is the part of the throat just behind the mouth. The major causes of oral cancer include tobacco use, areca nut chewing and heavy alcohol drinking; avoiding these can prevent the disease. Preceded by precancerous lesions, early oral cancers present as small painless ulcers or growths that can be detected, by careful physical examination, and if effectively treated by the physician. Prevention, early detection and treatment are effective interventions to reduce the worldwide burden of oral cancer. Early detection of oral cancer needs more than just understanding of the signs and symptoms of disease. The process must be managed effectively and handled sensitively. Every member of the dental team has a part to play and protocols should be developed for effective delivery of Dental and healthcare professionals have a crucial role to play in raising awareness of the dangers to oral health associated with smoking and the use of smokeless tobacco. Early detection of oral cancer needs more than just understanding of the signs and symptoms of disease. In its early stages, oral cancer can be treated in up to 90% of cases.Keywords
Oral Cancer, Early Detection, Prevention, Treatment.- DNA Vaccines: A Hope Full Ray in Immunology
Authors
1 College of Pharmacy (D. Pharm), Degaon, Satara, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 2 (2015), Pagination: 1-6Abstract
DNA vaccines uses foreign DNA to express an endcoded protein and stimulates the body's immune system. It represents a new approach to immunization which is potentially less expensive than the old vaccines. After inoculation into the host, DNA enters the cells, where the antigen is expressed , processed and subsequently recognized by immune system as in a natural infection. Certain methods like gene gun and elecroporation are used to deliver DNA vaccines.DNA vaccines undergo through clinical trials to find the way to treat autoimmune diseases, hepatitis, mycobacterial diseases, allergy and malaria. This review focuses on mechanism by which DNA vaccination induces immune response, delivering method and applications of DNA vaccinations.Keywords
DNA Vaccines, Mechanism, Delivering Methods.- Pharmacological Significance of Pyrazole and its Derivatives
Authors
1 Department of Pharmaceutics, Satara College of Pharmacy, Degaon, Satara-415004, (MS), IN
2 Satara College of Pharmacy (D. Pharm), Degaon, Satara-415004, (MS), IN